Top 30 ranked proteins from AD-related protein interaction network.

These proteins are shown with “UniProt Entry Name” as identifiers in the UNIPROT_ID column. The Node Degree column refers to the number of proteins directly interacting with the protein of interest found in the OPHID database. The protein ranking score RankNET Score is based on both network topology and quality score of each protein interaction involved, and is therefore not necessarily proportional to the protein's node degree. The proteins in this table are sorted by descending order of this score. The Occurrence column shows the document frequency for the protein observed from the 50,662 retrieved AD PubMed abstracts which contain the term “Alzheimer”. In the RankLIT column, the rank of 3,130 identified proteins from the retrieved AD PubMed abstracts is determined by descending order of document frequency for each protein. The Seed/Expanded column indicates that a protein is in the initial seed protein set (S) or the network-expanded protein set (E), where the AD relevance of the expended ones are judged on “disease-gene” association in OMIM (“*” refers to an AD-related protein).