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Focused PARP1 mutagenesis screen for talazoparib resistance in HeLa-PARP1-GFP and SUM149-GFP cells

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NIAID Data Ecosystem2026-03-10 收录
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HeLa-PARP1-GFP or SUM149-PARP1-GFP cells were mutagenised with pools of PARP1 CRISPR sgRNA vectors, selected in talazoparib, sorted for GFP expression and pooled RT-PCR products (reverse transcribed from GFP) from the resistant populations were sequenced.https://doi.org/10.1101/203224

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2018-02-28
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