Association between rt-PA and clinical outcomes in the full cohort.

OR: odds ratio, CI: confidence interval, ICH: intracranial hemorrhage. Neurological improvement was defined as a ≥4 point decrease in the NIHSS score during hospitalization or a NIHSS score of 0 at discharge. Good functional outcome was defined as an mRS score of 0–2 at discharge. Multivariable logistic model for neurological improvement, good functional outcome, and in-hospital mortality included age, sex, hypertension, dyslipidemia, diabetes, atrial fibrillation, smoking, drinking, chronic kidney disease, pre-stroke independency, previous stroke, previous ischemic heart disease, pre-antithrombotic therapy, cardioembolic stroke, admission within 2 h of onset, and NIHSS on admission. Multivariable logistic model for ICH, symptomatic ICH, and gastrointestinal bleeding included age, sex, systolic blood pressure, diabetes, chronic kidney disease, and NIHSS on admission.
Association between rt-PA and clinical outcomes in the full cohort.