The Gi numbers or annotation symbols of sequences that used in this study.

*In Drosophila melanogaster DTL/Moi is translated from the same transcription unit as the adjacent Tgs1 gene [49]. The structure of transcriptions unit(s) that specifies DTL/Moi and Tgs1 proteins varies among Drosophila species. In order to clarify the margins of analyzed sequences further general database reference was added to annotation symbols. Green background represents HOAP orthologs and paralogs while blue background represents HipHop orthologs and paralogs mentioned by Dubruille et al. [32]. (XLSX)