Comparative Toxicogenomics Database

The Comparative Toxicogenomics Database (CTD) advances understanding of the effects of environmental chemicals on human health. Biocurators manually curate chemical-gene, chemical-disease, and gene-disease relationships from the scientific literature. This core data is then internally integrated to generate inferred chemical-gene-disease networks. Additionally, the core data is integrated with external data sets (such as Gene Ontology and pathway annotations) to predict many novel associations between different data types. A unique and powerful feature of CTD is the inferred relationships generated by data integration that helps turn knowledge into discoveries by identifying novel connections between chemicals, genes, diseases, pathways, and GO annotations that might not otherwise be apparent using other biological resources.

比较毒理基因组学数据库（Comparative Toxicogenomics Database，CTD）旨在深化学界对环境化学物质影响人类健康机制的认知。生物编目人员会从科学文献中手动编目化学物质-基因、化学物质-疾病以及基因-疾病的关联关系。随后，该核心数据将在数据库内部完成整合，以生成推断型化学物质-基因-疾病关联网络。此外，该核心数据还会与外部数据集（如基因本体论（Gene Ontology，GO）注释、通路注释）进行整合，以此预测不同数据类型间的多种新型关联。CTD一项独特且极具价值的特性，是通过数据整合生成的推断关联：通过识别化学物质、基因、疾病、通路以及GO注释之间此前未被发现的关联，它能够帮助研究者将既有知识转化为全新的研究发现——而若使用其他生物信息学资源，这类关联往往难以被察觉。

搜集汇总

背景与挑战

背景概述

Comparative Toxicogenomics Database（CTD）旨在通过人工整理化学、基因和疾病之间的关联数据，促进对环境化学物质影响人类健康的理解。该数据库通过内部数据整合生成化学-基因-疾病网络，并结合外部数据集预测新型关联，其独特优势在于能够推断出其他生物资源中不易发现的潜在关系。