Genomic diversity and selection in the racing greyhound of Great Britain

The Greyhound, originally used for hunting, has been selected for competitive racing. Here, we present the first comprehensive population genomic analysis of racing Greyhounds (n=54) in the context of 14 other dog breeds (n=352) using 473K SNP genotypes. Inbreeding in the Greyhound (FROH = 0.47) was higher than most other breeds, reflecting positive selection for athletic traits but also raising concerns about potential health impacts. Although very long runs of homozygosity (ROH) were less common in the Greyhound than some breeds, large ROH islands suggest that selection for advantageous traits is relatively recent. Genomic regions under strong selection overlapped with ROH islands on CFA2, CFA4, CFA9, CFA10, CFA25, and CFA28, and contained candidate genes with marked allele frequency differences relative to other breeds. Notably, the strongest selection signal on CFA25 overlapped with the longest ROH island, encompassing the SLC46A3, POLR1D, FLT3, SLC7A1, MTUS2, LHFPL6, USPL1, and USP..., , # Genomic diversity and selection in the racing greyhound of Great Britain

Han, H., T.A. Blackett, M.L.H. Campbell, A.R. Holtby, B.A. McGivney, E.W. Hill

Dataset DOI: [10.5061/dryad.s4mw6m9k6](https://doi.org/10.5061/dryad.s4mw6m9k6)

**Dataset**

This repository contains genotype datasets in **PLINK binary format** (.bed, .bim, .fam). Two datasets are provided:

1. **69_GB_Greys_GP99**
2. **Combined_Final**

Each dataset consists of three coordinated files sharing the same filename prefix:

\<dataset>.bed   # Binary genotype file

\<dataset>.bim   # Variant information file

\<dataset>.fam   # Sample information file

These three files must always be used together.

* The .bed file contains the genotype matrix in compressed binary format and **cannot be opened as plain text**.
* The .bim and .fam files contain variant and sample metadata, respectively, and **can be opened as plain text** using a text editor.

The .bim file describes the variants (e.g., chromosome, position, alleles),...,