Engineered Tr1 cells designed for clinical use can eliminate primary pediatric AML blasts
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Purpose: To investigate the transcriptome of primary pediatric acute myeloid leukemia to identify molecular signatures correlated with sensitivity to LV-10 mediated killingMethod: RNA sequencing of polyA enriched pediatric acute myeloid leukemia bone marrow aspiratesResults: pAML killing sensitivity is associated with the expression of a myeloid maturation signature, while resistant pAMLs expressed a more stem cell-like signatureConclusions: Pediatric acute myeloid leukemia samples have different sensitivities to killing by LV-10 in vitro and the transcriptomes of killing-sensitive and killing-resistant lines differ
提供机构：
Stanford University
创建时间：
2022-02-20
