Engineered Tr1 cells designed for clinical use can eliminate primary pediatric AML blasts

Purpose: To investigate the transcriptome of primary pediatric acute myeloid leukemia to identify molecular signatures correlated with sensitivity to LV-10 mediated killingMethod: RNA sequencing of polyA enriched pediatric acute myeloid leukemia bone marrow aspiratesResults: pAML killing sensitivity is associated with the expression of a myeloid maturation signature, while resistant pAMLs expressed a more stem cell-like signatureConclusions: Pediatric acute myeloid leukemia samples have different sensitivities to killing by LV-10 in vitro and the transcriptomes of killing-sensitive and killing-resistant lines differ