Figure S1. E0 protein sequence alignment and epitope conservation analysis. Figure S2. E2 protein sequence alignment and epitope conservation analysis.
Available COVID-19 vaccines are primarily based on SARS-CoV-2 spike protein (S). Due to the emergence of new SARS-CoV-2 variants, other virus proteins with more conservancy, such as Membrane (M) prote
This study aimed to design a novel chimeric protein in silico to serve as a serotype-independent vaccine candidate against Shigella. The chimera contains amino acid residues 240–460 of Shigella invasi