Oral Microbiome in Esophageal Adenocarcinoma

The purpose of our study was to assess the influence of oral microbiota on the development of esophageal cancer. Our preliminary case-control studies reported a global alteration of foregut microbiome in esophageal adenocarcinoma with the strongest changes found in the oral microbiome. We hypothesise that commensal oral bacteria are capable of activating or degrading carcinogens in cigarette smoke and therefore may contribute to esophageal carcinogenesis. We conducted a prospective study nested in two large US cohorts, to determine whether oral microbiota are associated with subsequent esophageal adenocarcinoma.]]>
Incident cases were diagnosed with esophageal cancer any time after oral wash collection and had no prior cancer history (except non-melanoma skin cancer). Matched controls were selected at a case:control ratio of 2:1 by selecting participants who provided an oral wash sample in the same year as the case, had no cancer at or prior to case diagnosis date and were of the same sex, age and race as the case.]]>
This study was conducted between 2016-2018 at New York University School of Medicine. The biospecimen were drawn from the National Cancer Institute (NCI) Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial cohort, recruited in 1993-2001 and the American Cancer Society (ACS) Cancer Prevention Study II (CPS-II) Nutrition cohort, recruited in 1992 and sampled between 2000-2002.]]>