Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid

Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Wei Gu^1,2*, Andreas M. Rauschecker³, Elaine Hsu¹, Kelsey C. Zorn⁴, Yasemin Sucu¹, Scot Federman¹, Allan Gopez¹, Shaun Arevalo¹, Hannah A. Sample⁴, Eric Talevich⁵, Eric D. Nguyen¹, Marc Gottschall¹, Carl A. Gold⁶, Bruce A.C. Cree⁷, Vanja Douglas⁷, Megan B. Richie⁷, Maulik P. Shah⁷, S. Andrew Josephson⁷, Jeffrey M. Gelfand⁷, Steve Miller¹, Linlin Wang¹, Tarik Tihan⁸, Joseph L. DeRisi^4,9, Charles Y. Chiu^10,11, Michael R. Wilson⁷* ¹Department of Laboratory Medicine, University of California San Francisco, CA 94107, USA ²Department of Pathology, Stanford University, CA 94305, USA ³Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94107, USA ⁴Department of Biochemistry and Biophysics, University of California San Francisco, CA 94107, USA ⁵DNANexus, Mountain View, CA 94040, USA ⁶Department of Neurology, Stanford University, CA 94305, USA ⁷Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA 94107, USA ⁸Department of Pathology, University of California San Francisco, CA 94107, USA ⁹Chan Zuckerberg Biohub, San Francisco, CA 94107, USA ¹⁰UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA 91407, USA ¹¹Department of Medicine, Division of Infectious Diseases, University of California San Francisco, CA 94107, USA * Corresponding authors: Michael Wilson [e-mail], Wei Gu [e-mail]