File S1 - Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function

Contains Figures S1-S7. Figure S1, Examples of ICM tracings for (A) non-CF and (B) CF patients. Figure S2, Representative examples of CFTR inhibitor effects on CFTR currents in rectal biopsies. Figure S3, Effects of indomethacin on ICM parameters. Figure S4, Comparison of ICM parameters in Ringer’s buffer and RPMI + 25 mM HCO3 buffer. Figure S5, Comparison of sequential vs simultaneous agonist addition on CFTR detection by ICM. Figure S6, Comparison of four cold storage conditions on rectal biopsy performance. Figure S7, Comparison of CFTR-dependent ICM responses from forceps and suction biopsies in non-CF subjects. (DOC)