Two-level orthogonal screening designs with 24, 28, 32 and 36 runs

The potential of two-level orthogonal designs to fit models with main effects and two-factor interaction effects is commonly assessed through the correlation between contrast vectors involving these effects. We study the complete catalog of non-isomorphic orthogonal two-level 24-run designs involving 3–23 factors and we identify the best few designs in terms of these correlations. By modifying an existing enumeration algorithm, we identify the best few 28-run designs involving 3–14 factors and the best few 36-run designs in 3–18 factors as well. Based on a complete catalog of 7570 designs with 28 runs and 27 factors, we also seek good 28-run designs with more than 14 factors. Finally, starting from a unique 31-factor design in 32 runs that minimizes the maximum correlation among the contrast vectors for main effects and two-factor interactions, we obtain 32-run designs that have low values for this correlation. To demonstrate the added value of our work, we provide a detailed comparison of our designs to the alternatives available in the literature.