Asymmetric Total Synthesis of Griseofamine B and Its Three Stereoisomers
收藏NIAID Data Ecosystem2026-03-13 收录
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The first total synthesis of griseofamine B is described starting from l-4-bromo tryptophan methyl ester hydrochloride via five steps and in 18% overall yield. Its three stereoisomers were also synthesized following the same procedure with the yields of 5%, 19%, and 5%, respectively. In vitro antibacterial activities were also evaluated. All four compounds exhibited less potent activity than griseofamine A.
创建时间：
2022-03-03
