Published Orthogonal Replication, Independent External Asymmetry, a Five-World Assay Bridge, and a Collaborator-Ready Wet-Lab Execution Package of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#140, 2026-03-31)

This version fixes the next mature execution milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#140 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, exact same-core response algebra, a strict falsification protocol, an exhaustive assay scorecard, universal external quartet visibility, independent external asymmetry across BioGRID and CORUM, orthogonal functional validation in official DepMap matrices, a stable-side structural anchor in official human RCSB entries, stable-side repair-complex context in reviewed human UniProt GO Cellular Component annotations, a five-world assay bridge, and a final collaborator-ready wet-lab execution package. Across BioGRID, CORUM, DepMap, RCSB, and UniProt GO Cellular Component, the target remains the only analyzable family with world_pass_count = 5 while the background remains at 0. The new execution layer converts that bridge into a fixed first-run packet with 10 conditions (3 controls plus 7 experimental outsider states), 6 readout modules, and 9 adjudication gates (4 same-core geometry gates plus 5 bridge gates). This package contains milestone reports, claim documents, collaborator-facing execution materials, source notes, extracted evidence tables, source files, and publication materials for the first direct bridge from the Trinity computational fracture-state model to a lab-executable support-versus-failure run. This is a computational discovery and preregistration package and not a completed causal validation study.