Synthesis and Antiobesity Properties of 6‑(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2‑<i>d</i>]pyrimidin-4(3<i>H</i>)‑one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor
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数据链接：
https://figshare.com/articles/dataset/Synthesis_and_Antiobesity_Properties_of_6_4-Chlorophenyl_-3-_4-_3_3-difluoro-1-hydroxycyclobutyl_methoxy_-3-methoxyphenyl_thieno_3_2_i_d_i_pyrimidin-4_3_i_H_i_one_BMS-814580_A_Highly_Efficacious_Melanin_Concentrating_Hormone_Receptor_1_MCHR1_Inhibitor/3833010数据链接链接失效反馈
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资源简介：
The potent MCHR1 in vitro and in vivo antagonist activity of a series of cyclic tertiary alcohols derived from compound 2b is described. Subsequent pharmacokinetic and pharmacodynamic studies identified BMS-814580 (compound 10) as a highly efficacious antiobesity agent with a relatively clean in vitro and in vivo safety profile.
创建时间：
2016-10-07
