Gene Expression Profiling Identifies Potential Biomarkers for Vaso-Occlusive Episodes in Sickle Cell Disease

We performed bulk transcriptome profiling of a cohort of 174 individuals with SCD to identify potential biomarkers for VOE. We analyzed changes in the transcriptome of CD45+ leukocytes and CD71+ erythroid cells between steady state and VOE in individuals with SCD with or without chronic pain..