T cell-specific RIPK1 ablation results in villus atrophy of the duodenum in mice. T cell-specific RIPK1 ablation results in villus atrophy of the duodenum in mice

RIPK1 is required in T cells with a history of CD4-expression to maintain intestinal homeostasis. We show that the pathology in the upper intestine is a result of conventional T cell apoptosis in absence of the RIPK1. Overall design: Four samples in total: Two intraepithelial lymphocytes (IEL) samples: Ripk1FL/FL and Ripk1ΔCD4; Two lamina propria lymphocytes (LPL) samples: Ripk1FL/FL and Ripk1ΔCD4