Dietary Natural Melanin Nanozymes Delay Aging and Ameliorate Neurodegeneration via Improving Gut Microbiota and Redox Homeostasis

Aging is an inevitable multifactor process that causes
a decline
in organ function and increases the risk of age-related diseases and
death. Thus, the development of highly effective and safe therapeutic
strategies to delay aging and age-related diseases is urgently required.
In this study, we isolated natural melanin nanozymes (NMNs) from the
ink sacs of live octopuses. The NMNs exhibited excellent superoxide-dismutase-mimicking
and radical scavenging activities. In SAMP8 mice, treatment with NMNs
improved their cognition and memory functions while restoring their
aging-impaired liver function and lipid metabolism, thereby prolonging
their lifespan. Moreover, the NMNs reversed metabolic changes in their
aged brains and reconstructed their gut microbiota composition by
enhancing microbial community diversity. Our findings indicate that
NMNs treatment could be a promising approach for delaying aging and
preventing age-associated physiological decline in humans.