QS-DMD

In this study, we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease (QS-DMD) database ( http://www.qsdmd.lbci.net/ ), which includes diverse interactions for more than 8,000 drugs, 163 microbes, and 42 common diseases. Potential interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental validations.本研究开发了一套包含三个模块的系统化工作流程，用于构建基于群体感应（Quorum Sensing, QS）的药物-微生物-疾病（Quorum Sensing-based Drug-Microbe-Disease, QS-DMD）数据库（访问网址：http://www.qsdmd.lbci.net/）。该数据库涵盖了8000余种药物、163种微生物以及42种常见疾病的多样化相互作用数据。本研究针对微生物群体感应受体，结合基于分子对接的虚拟筛选技术与体外实验验证手段，系统探究了163种微生物与8000余种药物间的潜在相互作用。

搜集汇总

背景与挑战

背景概述

QS-DMD是一个基于群体感应（QS）的药物-微生物-疾病关联数据库，涵盖超过8000种药物、163个微生物簇和42种常见疾病。该数据库旨在深化对个性化医疗的理解，并推动潜在疾病疗法的开发。