p-Y348-SYK binds VAV family
收藏reactome.org2025-03-23 收录
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The SH2 region of Vav1 binds to Syk at a site including phosphorylated tyrosine Y348. Mutation of this residue to F abolishes binding and subsequent Vav1 phosphorylation. Vav2 has also been shown to bind Syk.
Vav1蛋白的SH2结构域在包含磷酸化酪氨酸Y348的位点与Syk结合。将该位点上的氨基酸突变至F，将导致结合作用及随后的Vav1蛋白磷酸化反应的丧失。研究亦证实Vav2蛋白能与Syk结合。
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