cDNA sequencing of Plasmodium falciparum field parasites 2015-2018

The objective of this study is to characterize gene expression signatures associated with in vivo artemisinin resistance phenotype and its transcriptional response to Artemisinin Combination Therapy (ACT) treatment . RNA-seq was applied to establish the global gene expression profiles for 196 and 180 isolates sampled from patients prior to and post to ACT treatment. P. falciparum isolates were sampled from the whole blood of patients from 6 countries and 13 sites across Southeast Asia (Ramu in Bangladesh; Thabeikkyin, Pyay, Pyin Oo Lwin and Ann in Myanmar; Phusing and Khun Han in Thailand; Pailin, Pursat, Ratanakiri and Preah Vihear in Cambodia; Sekong in Laos; Bin Phuoc in Vietnam) from 2015 to 2018.