Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response

To investigate the inhibition effect of DYRK1B kinase function on human naïve CD4+ T cell differetionation which stimulated under Treg polarizing condition for 24 hours. We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different sample. Comparative gene expression profiling analysis of RNA-seq data for stimulated native CD4+ Tcells treated with a selective inhibitor and non-treated cells