Rhodium-Catalyzed Merging of 2‑Arylquinazolinone and 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Monofluoroolefin Quinazolinone Derivatives

An efficient method for the synthesis of 2-(o-monofluoroalkenylaryl)­quinazolinone derivatives was developed. In this context, the quinazolinone ring served as the inherent directing group, 2,2-difluorovinyl tosylate was used as the monofluoroolefin synthon, and Rh­(III)-catalyzed C–H bond difluorovinylation of 2-arylquinazolinons was performed to give the corresponding monofluoroalkene-containing quinazolinons in yields of 65–92%. The method is characterized by broad synthetic utility, mild conditions, and high efficiency.