The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution. The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution

We investigated natural inter-individual variation of the epigenome in a quantitative manner. To probe the degree of natural epigenomic diversity in S. cerevisiae, we compared three unrelated wild strains using replicated Mnase-seq and ChIP-seq profiling at mononucleosomal resolution for five histone marks (H3K4me3, H3K9ac, H3K14ac and H4K12ac and H3K4me1).