Novel Macrophage Subpopulation Linked to CAD: raw and processed data files

This directory contains all single-cell datasets analyzed in the "Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying increased genetic risk of coronary artery disease". Associated scripts are available at https://github.com/jhjiang2020/multiome_paper. 

Jan 2025 updates: include the 10x Cell Ranger ARC output for the scATAC-seq assay. Please note that 10x peaks were not used for downstream analyses. Instead, we trimmed the atac-seq fragments to retain the 9bp Tn5 cut sites at both ends and aggregated into one consensus bed file. We then recalled peaks using `MACS3 --qvalue 1e-5 --nomodel --shift -50 --extsize 100  --broad` (see discussion in https://github.com/stuart-lab/signac/issues/682).