Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, SODIUM ION, ... Authors: Wong-Roushar, J, Dann III, C.E. Deposit date: 2020-07-18 Release date: 2021-03-31 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.455 Å) Cite: Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
创建时间：
2020-07-18
