Comparison of group least squares means (± SEM) of hematopoietic cellularity, adiposity, and bone volume in intact (I) and ovariectomized (OVX) mice without radiation (−R) and with radiation (+R) 30 days after radiation treatment.

Within columns, identical letters indicate relevant statistically significant differences between groups at p≤0.001). Radiation significantly reduced hematopoietic cellularity in intact mice, but the effect was more severe in OVX (interaction F = 4.79, p = 0.0439). OVX alone had no effect on hematopoietic activity in the absence of radiation. Radiation significantly increased marrow adipose only in OVX (interaction F = 10.14, p = 0.0062), and OVX increased marrow fat without and with radiation treatment. Radiation significantly reduced BV/TV% (p = 0.0467), but OVX had no additive effect. All statistical analyses were based on two-way ANOVA.