Human cancers arising from different cell lineages display genotypes with characteristic features, but the lineage-specific factors that influence the differences in genetic profiles have not been ide

NIAID Data Ecosystem20

Mouse small cell lung cancer model

小细胞肺癌模型

基因表达分析

A mouse model for human small cell lung carcinoma (SCLC) has been developed based on evidence in human tumors that the tumor suppressor functions of RB and p53 are defective in more than 90% of SCLC c

NIAID Data Ecosystem10

Comparison of gene expression patterns of two SCLC genetically-engineered mouse models; Rb1 floxed, Trp53 floxed, LSL-Myc T58A-IRES-Luc vs. Rb1 floxed, Trp53 floxed, Rbl2 (p130) floxed. Mus musculus

小细胞肺癌模型

肿瘤基因表达分析

Myc expression cooperates with Rb1 and Trp53 loss in mouse lungs to generate rapid, aggressive, highly metastatic and neuroendocrine-low tumors that are similar to human variant subset of SCLC with hi

NIAID Data Ecosystem30

Whole exome sequencing of Rb1 and Trp53 deficient (RP) SCLC mouse model. Whole exome sequencing of Rb1 and Trp53 deficient (RP) SCLC mouse model

小细胞肺癌模型

拷贝数变异分析

Whole exome sequencing of a cell line derived from an Rb1 and Trp53 genetically engineered mouse model (GEMM) to assess the baseline copy number landscape of the cells prior to experimental modificati

NIAID Data Ecosystem20

3prime RNA-seq of murine SCLC cell line modified with CRISPR-activation of Myc, Mycl or Mycn

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