A Potential Role of the Unfolded Protein Response in the Impaired Production and Release of Epinephrine in Recurrent Hypoglycemia

In order to gain further insight into the molecular mechanism(s) mediating the blunted epinephrine responses following recurrent hypoglycemia we utilized global gene expression profiling approach. Our results indicate the association between defective counterregulation (impaired epinephrine release) and the activation of the unfolded protein response as well as increased neuropeptide signaling, altered ion homeostasis and downregulation of proteins involved in Ca2+-dependent exocytosis of secretory vesicles.为进一步阐明介导反复低血糖后肾上腺素应答钝化的分子机制，我们采用了全基因组基因表达谱分析手段。本研究结果表明，对抗调节缺陷（即肾上腺素释放受损）与未折叠蛋白反应（unfolded protein response）的激活、神经肽信号通路增强、离子稳态失衡以及参与钙依赖性分泌囊泡胞吐作用的蛋白质表达下调之间存在关联。