Local and systemic multiomics signature of eosinophilic esophagitis (EO) in children

We aimed to provide the most comprehensive description to date of both local and systemic immune constituents characterizing children with EO. For that purpose, we performed comprehensive immunophenotyping and cytokine/antibody measurements on paired biopsies and blood samples collected from children with EoE, in comparison to age-matched controls. EoE status was clinically and histologically characterized and confirmed using transcriptomer analysis. As a second objective, we aimed to identify an EoE signature in the periphery by combining the comprehensive analysis of circulating immune components and non-targeted metabolomics on plasma. Ten individuals affected by eosinophilic esophagitis (EO) and ten controls (CT) were studied. The analyses were carried out by comparing EO to CT