Direct reprogramming from fibroblasts to neurons induces widespread cellular and transcriptional reconfigurations. In this study, we characterized global epigenomic changes during direct reprogramming

NIAID Data Ecosystem50

细胞重编程表观遗传学

癌症表观遗传学

The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to s

NIAID Data Ecosystem40

Cellular identity loss occurring during both iPS cells generation and malignant transformation can be followed using the somatic markers Thy1 and Bcl11b (ATAC-seq). Cellular identity loss occurring during both iPS cells generation and malignant transformation can be followed using the somatic markers Thy1 and Bcl11b (ATAC-seq)

细胞重编程表观遗传学

细胞可塑性

Coordinated changes of cellular plasticity and cellular identity are critical for pluripotent reprogramming and oncogenic transformation. However, the sequences of cellular/molecular events that orche

NIAID Data Ecosystem60

CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of inflammatory monocyte-derived cells. CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of inflammatory monocyte-derived cells

纤维化分子机制

细胞重编程表观遗传学

Fibrosis is a condition shared by numerous inflammatory diseases. The molecular mechanisms underlying fibrosis have remained incompletely understood severely hampering drug development. CXCL4 is assoc

NIAID Data Ecosystem50

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms

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