PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane

At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

在高尔基膜上，磷脂酰肌醇磷酸酶SAC1（SACM1L）高效地将磷脂酰肌醇-4-磷酸（PI4P）去磷酸化，在一定程度上也作用于磷脂酰肌醇-3-磷酸（PI3P），最终转化为磷脂酰肌醇（PI）。然而，该酶对磷脂酰肌醇-3,5-二磷酸（PI(3,5)P2）的活性并无显著作用（Rohde等人，2003年）。