Differences of actionable genomic alterations between patients with and without chronic gastritis in esophageal cancer. Homo sapiens

In this study, we carried out targeted next-generation sequencing (NGS) of tumor tissues and paired blood samples from patients with esophageal cancer using a hybridization capture-based panel. The differences in somatic mutations, somatic interactions, key signaling pathways, functional biological information, and clinical actionability for the therapy of targeted agents were explored between patients with and without chronic gastritis in esophageal cancer.