Differentially expressed genes in certinib-resistant NB-1 xenografts
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE82143
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The goal of this study is to elucidate the molecular mechanism that allowed NB-1 xenograft tumors to grow out in the presence of continued ALK inhibition. Poly(A)-selected RNA was extracted from tissues of NB-1 tumors that progressed on ceritinib treatment and those treated with a vehicle to identify differentially expressed genes between these two groups. mRNA profiles of NB-1 xenograft tumors that progressed on ceritinib treatment and those treated with a vehicle were generated by RNA sequencing, in duplicate, using Illumina HiSeq 2500.
创建时间:
2019-09-02



