DNA Methylation profiles of benzene hematotoxicity

To identify potential methylation biomarkers in occupationally benzene-exposed individuals and to elucidate mechanisms of benzene hematotoxicity. Bisulfite converted DNA from peripheral blood mononuclear cells of four patients of chronic benzene poisoning, four workers exposed to benzene levels ranging from < 1 ppm and four health controls matched age and gender without benzene exposure samples was hybridized to the Illumina Infinium HumanMethylation450 BeadChip array.