Gene Expression Profile of Diffuse Large B-Cell Lymphoma Cells upon inhibition of PIM kinanses. Gene Expression Profile of Diffuse Large B-Cell Lymphoma Cells upon inhibition of PIM kinanses

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL)-derived cell lines exposed to the pan-PIM inhibitor MEN1703 was performed to investigate transcriptional consequences of PIM kinase inhibition in DLBCL and to identify treatment-related changes in the signalling pathways. Overall design: Cells at density 0.5x10E6/ml were treated in biological replicates with DMSO (control) alone or 1.5 µM MEN1703 for 24 hours.