miRNA and mRNA transcriptome profiling of chondrocytes in proliferative zone of acetabular cartilage in developmental dysplasia of the hip

Developmental dysplasia of the hip (DDH) is a complex and multifactorial disease with an unclear pathogenesis, and the non-coding RNAs have been found important effect in many diseases. However, their contributions to the pathogenesis of DDH are not well-established. Growth of the acetabular cartilage mainly depends on the regulation of chondrocytes in proliferative zone. Here, we report on some new regulatory mechanisms of gene expression underlying the development of DDH by transcriptome profiling of proliferative zone microdissected from the acetabular cartilage. These results provide original insight into the roles of non-coding RNAs in DDH and provide a valuable resource for further analyses of molecular mechanisms and signaling networks.发育性髋关节发育不良（Developmental dysplasia of the hip, DDH）是一种病因未明的复杂多因素疾病，非编码RNA（non-coding RNAs）已被证实对多种疾病发挥关键调控作用。然而，其在发育性髋关节发育不良发病机制中的具体贡献尚未得到明确阐释。髋臼软骨（acetabular cartilage）的生长主要依赖于增殖区（proliferative zone）内软骨细胞（chondrocytes）的调控。本研究通过对髋臼软骨中显微切割获取的增殖区组织开展转录组分析（transcriptome profiling），揭示了发育性髋关节发育不良发生过程中基因表达的全新调控机制。本研究结果为阐明非编码RNA在发育性髋关节发育不良中的作用提供了原创性视角，同时为后续分子机制与信号网络的深入研究提供了宝贵的研究资源。