Effects of pirimiphos-methyl on Atlantic salmon in vivo

The use of plant-based feeds has introduced undesirables, such as pesticides, that have previously not been associated with seawater farming of fish species such as Atlantic salmon. Earlier wide-scope chemical screening showed that the organophosphate pirimiphos-methyl (PM) is one of the most prevalent pesticides present in commercially produced Atlantic salmon feed. Information on the safe upper limit of background levels of PM-m in Atlantic salmon feeds with regards to possible adverse effect on fish health is lacking. Therefore, Atlantic salmon (132 g) were fed graded levels of PM spiked feeds (0, 0.35, 1.5, 5, and 22 mg/kg) in triplicate for 3 months. The goal was to investigate the transcriptomic response of PM exposure in salmon.