Normalized DO mouse phenotypes.

Contains Mouse IDs, covariates used in phenotype processing, and z-score normalized phenotype values. ‘Mouse_ID’ is a unique identifier corresponding to each unique animal and includes study information. ‘Age’ is a covariate corresponding to the age of each animal at the time of phenotyping. For certain animals, different phenotypes were collected at different ages; for these animals, ‘Age’ is recorded as “variable”. ‘Sex’ corresponds to the sex of the animal (‘F’ for female and ‘M’ for male). ‘Diet’ corresponds to the dietary intervention group for each animal in the DRiDO study [18], but may also correspond to the number of days on a high fat diet (animals from the Svenson high-fat diet study, denoted as ‘Sven_HFD’ [Gatti et al. 2017]) or pharmacological intervention (e.g., lifespan data from [78]). ‘Genwave’ corresponds to the DO generation of each animal. Additional columns correspond to various z-score normalized phenotypes after correction for the aforementioned covariates. Phenotype names contain a prefix corresponding to the study from which they were collected: ‘attie’ (pancreatic phenotypes from [53]), ‘bone’ (bone strength phenotypes from [23]), ‘cal_cr’ (DRiDO phenotypes from [18]), ‘cal_int’ (newly published frailty, aorta, and lung phenotypes), ‘catnap’ (metabolic cage data from [11]), ‘ches_striatum’ (phenotypes from [20]), ‘lifespan’ (lifespan data from independent lifespan studies analyzed in [78]; ‘shock’ and ‘har’ correspond to the Shock and Harrison studies, respectively), ‘pazdro_heart’ (cardiac phenotypes from [22]), and ‘Sven_HFD’ (various phenotypes from [21]). Phenotypes may also contain a suffix corresponding to dietary intervention groups from the DRiDO study: ‘AL’ (ad libitum), ‘20’ (20% caloric restriction), ‘40’ (40% caloric restriction), ‘1D’ (one-day intermittent fasting), ‘2D’ (two-day intermittent fasting). Phenotypes from the DRiDO study collected annually or bi-annually will contain timepoint information corresponding to the year of the study in which they were collected (‘Y1’ - ‘Y4’). Biannual measurements are labeled with ‘A’ or ‘B’, corresponding to the first or second annual time point. (ZIP)