Motor response with apomorphine sublingual film and levodopa in patients with OFF episodes supplementary appendix

Aim: Evaluate timing of motor improvement with carbidopa/levodopa (CD/LD) and apomorphine
sublingual film (SL-APO) in patients with Parkinson’s disease and OFF episodes. Methods: A post hoc
pooled analysis from two studies assessed Movement Disorder Society Unified Parkinson’s Disease Rating
Scale Part III (MDS-UPDRS-III) scores and investigator-rated FULL ON. Results: At 15 and 30 min following
the prescribed first daily CD/LD dose, mean improvements in MDS-UPDRS-III scores were -6.7 and -16.3,
respectively, and FULL ON was achieved by 6.5 and 41.8% of patients. Following an optimized SL-APO
dose, mean improvements in MDS-UPDRS-III scores were -13.9 and -22.9, and FULL ON was achieved by
34.7 and 81.0% of patients. Conclusion: Concomitant administration of SL-APO with carbidopa/levodopa
may be useful for delayed ON.