Synthesis of Glycomimetics by Diastereoselective Passerini Reaction
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https://figshare.com/articles/dataset/Synthesis_of_Glycomimetics_by_Diastereoselective_Passerini_Reaction/7247174
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We describe the utilization of bis-isopropylidene-protected d-fructose-derived aldehyde in the Passerini reaction with various acids and isocyanides. A library of densely functionalized glycomimetics bearing up to 3 carbohydrate units was obtained in high yields and diastereoselectivities. The configuration of the newly formed stereocenter was determined and the diastereoselectivity was rationalized by DFT calculations.
创建时间：
2018-10-24
