PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
收藏reactome.org2025-01-22 收录
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PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).
PARP1 或 PARP2 同源二聚体或异源二聚体,与单链DNA(ssDNA)结合,在单链断裂(SSB)处与POLB和FEN1相互作用,经历渐进性自-PAR化过程,导致PARP1/PARP2发生多(ADP-核糖)聚化(Satoh 等人,1994年,Prasad 等人,2001年)。
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