Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms

Zinc is an essential micronutrient that is believed to influence gut homeostasis by unclear mechanisms. Jimenez et al. identify that zinc transporter Zip14 is essential to maintain protective systems, lower inflammation, and limit dysbiosis through mechanisms that control histone deacetylase activity and transcription factor occupancy of specific genes in intestinal epithelial cells. We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 WT and 5 Zip14 KO mice.锌（Zinc）是一种必需微量营养素，据信可通过尚未阐明的机制影响肠道稳态。Jimenez等（Jimenez et al.）的研究证实，锌转运蛋白Zip14（Zinc transporter Zip14）在维持肠道保护系统、降低炎症水平及限制菌群失调方面发挥关键作用，其作用机制为调控肠上皮细胞内特定基因的组蛋白去乙酰化酶活性与转录因子结合占有率。随后，我们基于5只野生型（WT，Wild Type）小鼠与5只Zip14基因敲除（KO，Knock Out）小鼠的RNA测序（RNA-seq）数据开展了基因表达谱分析。