Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion [RNA-seq]

This study comprehensively profiles the mSWI/SNF complexes throughout acute and chronic T cell stimulation, with and without small molecular inhibitors and degraders. Specifically, we find pan SWI/SNF and complex specific roles in both activation and exhaustion. Comparative gene expression profiling analysis of RNA-seq data of CD3/CD28 activated Human Primary CD8 positive T cells with and without treatment of mSWI/SNF inhibitors or degraders and of CD3/CD28 activated Mouse Primary CD8 positive T cells with and without treatment with mSWI/SNF inhibitors.