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Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercapto­acetaldehyde

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https://figshare.com/articles/dataset/Domino_Synthesis_of_Tetrasubstituted_Thiophenes_from_1_3_Enynes_with_Mercapto_acetaldehyde/3100708
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Domino synthesis of tetrasubstituted thiophenes is described from 1,3-enynes and mercapto­acetaldehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidation sequence under air. The broad substrate scope and mild reaction conditions are significant practical features.
创建时间:
2016-03-14
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