File S1 - Investigating microRNA-Target Interaction-Supported Tissues in Human Cancer Tissues Based on miRNA and Target Gene Expression Profiling

Figure S1–S3. Figure S1. Summary of the correlations of 743 MTIs (miRTarBase) across all 89 tissues. a. The proportion of negative correlations is near 50%. b. The amount of correlations between −0.5 and 0.5 is larger than 90%. Both results reveal that there are no significant correlations among MTIs using this data source across all 89 tissues. Figure S2. The expression levels of hsa-miR-122 and hsa-let-7a in 89 tissues The red line is a cutoff line, and the cutoff value is 7.25 (after log2 transformed). The data were eliminated when the expression level was lower than the cutoff line (Huang et al. 2007). Figure S3. Comparison of selected results and permutation results. (a)(b) Loss function values of each miRNA and its targets across MTI-supported tissues and permutation tissues. (RAR)