Comparisons of the frequencies of antibodies against common infectious agents.

*p = 0.0119, compared with IgG abnormality (−) MS patients.**p = 0.0451, compared with HCs.***p = 0.0474, compared with HCs.*,**,***Significant difference between the linked values (pThe age of the patients during examination did not differ significantly among HCs and MS patients, regardless of the presence or absence of IgG abnormality (mean ± SD in years: 37.21±12.54 for MS; 36.19±11.36 for IgG abnormality-positive MS; 39.00±14.39 for IgG abnormality-negative MS; and 38.93±12.11 for HCs).CSF, cerebrospinal fluid; EBV, Epstein-Barr virus; HCs, healthy controls; MS, multiple sclerosis; pcorr, corrected p value; VZV, varicella zoster virus.