Mesodermal commitment pathway

Model depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2857 CPTAC Assay Portal]

本模型基于文献记载及通过对数十个独立诱导及胚胎多能干细胞系进行分化至多个谱系（外胚层、中胚层、内胚层、胚胎体）后的高度富集基因表达谱比较，描绘了中胚层定向的模型。相关基因组数据可从以下链接获取：https://www.synapse.org/#!Synapse:syn1773109。该途径上的蛋白质具有通过[https://assays.cancer.gov/available_assays?wp_id=WP2857 CPTAC 测定门户]提供的靶向检测方法。