gonads gene expression profiling in WT and Sox9flox/flox; Sf1:creTr/+ mice

In mammals, gonadal differentiation is the first step of sex determination, and the transcription factor Sox9 promotes testis differentiation. Here we used the XY Sox9flox/flox; Sf1:creTr/+ mouse model and show that the lack of Sox9 expression induces a full sex reversal of E13.5 XY Sox9flox/flox; Sf1:creTr/+ gonads compared to XY Sox9flox/flox. Keywords: gonads gene expression profiling in WT and Sox9flox/flox; Sf1:creTr/+ mice 3 WT versus 3 Sox9flox/flox; Sf1:creTr/+ mice.在哺乳动物中，性腺分化是性别决定的首要步骤，转录因子Sox9（Sox9）可促进睾丸分化。本研究采用XY型Sox9flox/flox; Sf1:creTr/+小鼠模型，实验结果显示，相较于XY型Sox9flox/flox小鼠，Sox9表达缺失可诱导胚胎发育第13.5天（E13.5）的XY型Sox9flox/flox; Sf1:creTr/+小鼠性腺发生完全性反转。关键词：野生型（Wild Type）与Sox9flox/flox; Sf1:creTr/+小鼠的性腺基因表达谱分析；3只野生型小鼠与3只Sox9flox/flox; Sf1:creTr/+小鼠。